Minocycline Oral antibiotics - most widely prescribed agents in acne Dose -100-200 mg daily Indicated for severe acne, moderate facial acne not responding to topical therapies and/or extensive truncal acne. Adverse effects with minocycline include drug hypersensitivity syndrome (DHS) - within 3 months of treatment initiation characterized by fever, malaise, ahralgia and a diffuse exanthematous skin eruption. lupus?like reaction Hyperpigmentation of skin & nails Melanonychia (dark nails)