A 35 year old female non-smoker has adeno-carcinoma of lung. Which one of the following immunohistochemical marker is used for detection of adenocarcinoma of lung?
Correct Answer: Thyroid transcription factor
Description: Ref:Textbook of pathology (Harsh mohan) 6th edition,page no.500 Immunohistochemical marker used for detection of adeno-carcinoma of lung for a 35 year old female non-smoker is Thyroid transcription factor Adenocarcinoma: Adenocarcinoma, also calledperipheral carcinoma due to its location and scar carcinoma due to its association with areas of chronic scarring, is themost common bronchogenic carcinoma in women and isslow-growing. Recent estimates on adenocarcinoma place this as the most frequent histologic subtype of lung cancer.Adenocarcinoma is fuher subclassified into 4 types: i) Acinar adenocarcinoma which has predominance of glandular structure and often occurs in the larger bronchi. ii) Papillary adenocarcinoma which has a pronounced papillary configuration and is frequently peripherally located in the lungs and is found in relation to pulmonary scars (scar carcinoma). iii) Bronchiolo-alveolar carcinoma is characterised by cuboidal to tall columnar and mucus-secreting epithelial cells growing along the existing alveoli and forming numerous papillary structures . Ultrastructurally, these tumour cells resemble Clara cells or less often type II pneumocytes. iv) Solid carcinoma is a poorly-differentiated adenocarcinoma lacking acini, tubules or papillae but having mucuscontaining vacuoles in many tumour cells.
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Pathology
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