Medical MCQ - A 3-year-old boy is admitted to the hospital with signs of acute renal failure. Radiologic studies reveal that the boy has bilateral masses involving both kidneys. Examination of biopsy material confirms the diagnosis of Wilms tumor. Which of the following gene mutations is the most common in Wilms tumor?

A 3-year-old boy is admitted to the hospital with signs of acute renal failure. Radiologic studies reveal that the boy has bilateral masses involving both kidneys. Examination of biopsy material confirms the diagnosis of Wilms tumor. Which of the following gene mutations is the most common in Wilms tumor?

The gene responsible for WT1

The gene responsible for HGF

The gene responsible for VEGF

The gene responsible for GDNF

Question Category:

Anatomy

Correct Answer:

The gene responsible for WT1

Description:

Wilms tumor is a kidney malignancy that usually occurs in children. It has recently been shown that it can be caused by mutations in the WT1 gene, behaving according to Knudson's two-hit model for tumor suppressor genes.

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