A 29-year-old patient presents with focal seizures. MRI shows frontal and temporal enhancement. What is the most probable diagnosis?
Correct Answer: Herpes simplex encephalitis
Description: In children and young adults, primary HSV infection can lead to encephalitis, by the neurotropic spread of the virus from periphery olfactory bulb.In other majorities of cases, there is the prior mucocutaneous HSV-1 infection which gets reactivated.The Clinical hallmark of HSV infection includes acute onset of fever, and focal neurological symptoms and signs, especially of the temporal lobe.Diagnosis :CSF protein and CSF lymphocytosis Brain biopsy is the gold standardHSV DNA detection in CSF by PCR has largely replaced biopsyTreatment: IV acyclovir
Category:
Microbiology
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