A 25-year-old man presents with low grade fever, weight loss, fatigue, crampy abdominal pain, episodic diarrhea & postprandial bloating. Right lower quadrant tenderness is elicited on palpation of abdomen. A capsule endoscopy reveals thickening of terminal ileum, edema, marked luminal narrowing, and a cobblestone appearance of the mucosa. Which of the following is a characteristic of this condition?