A 25-year-old female presented in the month of December with chronic fatigue, cyanosis with bluish lips and ahralgia. Peripheral blood film is shown below. What is the likely cause?
Correct Answer: Cold AIHA
Description: The given figure is of RBC agglutination. The history is suggestive of agglutination occurring in the month of December that is cold induced. Cold Agglutinin AIHA immune hemolytic anemia caused by IgM antibodies that bind red cells avidly at low temperatures (0deg-4degC). antibodies appear transiently following ceain infections, such as with Mycoplasma pneumoniae, EBV, CMV, influenza virus, and HIV. Clinical symptoms result from binding of IgM to red cells in vascular beds where the temperature may fall below 30degC, such as in exposed fingers, toes, and ears.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now