A 23-year-old female underwent kidney transplantation. After 8 days, she suffered from acute humoral rejection. She was successfully managed with tacrolimus and one more drug that suppressed B and T lymphocytes. Drug which target both B and T lymphocytes inhibiting de novo synthesis of purines is?
Correct Answer: Mycophenolate mofetil
Description: Mycophenolic acid is formed from mycophenolate mofetil. It inhibits inosine monophosphate dehydrogenase, the rate limiting enzyme in the de novo pathway of purine synthesis. This action suppresses both B and T-lymphocytes.
Category:
Pharmacology
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