A 20-year-old patient weighing 60 kg has to be prescribed an antiepileptic drug (available
as 200 and 400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters
and therapeutic plasma concentration of the selected drug are:
Target steady-state plasma concentration (Cpss) – 6 mg/L
Oral bioavailability (F) – 70%
Volume of distribution (V) – 1.4 L/kg
Clearance (CL) – 80 ml/hr/kg
Plasma half life (t½) – 15 hours
What should be the loading dose and the daily maintenance dose of the drug for this patient?
A 20-year-old patient weighing 60 kg has to be prescribed an antiepileptic drug (available
as 200 and 400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters
and therapeutic plasma concentration of the selected drug are:
Target steady-state plasma concentration (Cpss) – 6 mg/L
Oral bioavailability (F) – 70%
Volume of distribution (V) – 1.4 L/kg
Clearance (CL) – 80 ml/hr/kg
Plasma half life (t½) – 15 hours
What should be the loading dose and the daily maintenance dose of the drug for this patient?
💡 Explanation
A 20-year-old patient weighing 60 kg has to be prescribed an antiepileptic drug (available
as 200 and 400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters
and therapeutic plasma concentration of the selected drug are:
Target steady-state plasma concentration (Cpss) – 6 mg/L
Oral bioavailability (F) – 70%
Volume of distribution (V) – 1.4 L/kg
Clearance (CL) – 80 ml/hr/kg
Plasma half life (t½) – 15 hours
What should be the loading dose and the daily maintenance dose of the drug for this patient?
✓ Correct Answer: A. 720 and 984 mg respectively
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