A 20 year old male patient came with the complaint of a decrease in the urinary output to about 400ml/day. Both RBF and GFR were decreased. Which of the following causes a decrease in both RBF and GFR?
Correct Answer: Only afferent aeriolar constriction
Description: Constriction of either the afferent or efferent aeriole increases resistance, and according to Equation Q = DP/R, an increase in resistance (R) decreases flow (Q) (i.e., RBF). Dilation of either the afferent or efferent aeriole increases flow (i.e., RBF). Constriction of the afferent aeriole (A) decreases P GC because less of the aerial pressure is transmitted to the glomerulus, thereby reducing GFR. Dilation of the afferent aeriole increases P GC because more of the aerial pressure is transmitted to the glomerulus, thereby increasing GFR.Reference: Berne and Levy Medical Physiology; 6th edition; Page no: 574
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Physiology
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