A 20 year old female is diagnosed with granulosa cell tumor of the ovary. Which of the following biomarkers would be most useful for follow-up of patient?
Correct Answer: Inhibin
Description: Inhibin is secreted by granulosa cells and elevated tissue and serum levels of which are useful for identifying granulosa tumor and monitoring treated patients. Mutations of the FOXL2 gene is observed in 97% of adult granulosa cell tumors. Granulosa cell tumor: Marker is inhibin. Inhibin has been studied in women with granulosa cell tumors. It is a peptide hormone produced by ovarian granulosa cells that play a role in the regulation of FSH secretion by the pituitary. It is composed of an alpha subunit and 1 of 2 beta subunits (BA or BB). Although inhibin A and inhibin B levels can both be elevated in patients with granulosa cell tumors, inhibin B level is usually elevated in a higher propoion of these tumors.
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now