A 15-year-old boy presented with one day history of bleeding gums, subconjunctival bleed and purpuric rash. Investigations revealed the following results: Hb-6.4 gm/dL; TLC-26,500/mm3 Platelet 35,000 mm3; prothrombin time-20 sec with a control of 13 sec; paial thromboplastin time-50 sec; and Fibrinogen 10mg/dL. Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?
Correct Answer: Promyelocytic leukemia
Description: The child presented with acute onset of bleeding, along with the following laboratory findings: Thrombocytopenia (35000/mm3 as compared to normal value of 1, 50,000/mm3) Increased prothrombin time (20s as compared to control of 13s) Increased paial thromboplastin time (50s vs. normal 26-32s) Decreased fibrinogen (10 mg/dL vs. normal of 233- 496 mg/dl) These hematological abnormalities indicate disseminated intravascular coagulation. Most common form of AML associated with DIC is M3-AML (Acute promyelocytic leukemia). All-trans retinoic acid (ATRA), an analogue of vitamin A induce the neoplastic promyelocytes to differentiate into neutrophils rapidly and decrease chance of DIC. other agent useful is AsO3(arsenic trioxide).
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now