A 14 year old boy complains with gingival bleeding, oral ulcers, anemia with hepatomegaly but no lymphadenopathy, total leukocyte count of one lakh cells per mm3 is suffering from:
Correct Answer: Acute myeloid leukemia
Description: Oral and periodontal manifestations of leukemia may include leukemic infiltration, bleeding, oral ulcerations, and infections. The expression of these signs is more common with acute and subacute forms of leukemia than with chronic forms.
Leukemic cells can infiltrate the gingiva and, less frequently, the alveolar bone. Gingival infiltration often results in leukemic gingival enlargement leukemia. Highest incidence is seen in patients with acute monocytic leukemia (66.7%), followed by those with acute myelocytic–monocytic leukemia (18.7%) and acute myelocytic leukemia (3.7%). It should be noted, however, that monocytic leukemia is an extremely rare form of the disease. Leukemic gingival enlargement is not found in edentulous patients or in patients with chronic leukemia, suggesting that it represents the accumulation of immature leukemic blast cells in the gingiva adjacent to tooth surfaces with bacterial plaque.
The French-American-British (FAB) classification is an older system for describing AML, but it is still commonly used and is listed below for reference.
MO: Myeloblastic without differentiation
M1: Myeloblastic with little or no maturation
M2: Myeloblastic with maturation
M3: Promyelocytic
M4: Myelomonocytic
M4eo: Myelomonocytic with eosinophils
M5a: Monocytic without differentiation (monoblastic)
M5b: Monocytic with differentiation
M6: Erythroleukemic
M7: Megakaryocytic
Reference: Carranza Periodontology 13th ed page no 214
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now