A 10-month-old patient with recurrent pyogenic infections, eczema, and severe bleeding (thrombocytopenia) is diagnosed with Wiskott-Aldrich syndrome. This immune disorder is usually associated with which of the following?
Correct Answer: Humoral Immunity - Deficient; Cellular Immunity - Deficient
Description: Immunodeficiency disorders can be categorized according to whether the defect primarily involves humoral immunity (bone marrow derived, or B lymphocytes) or cellular immunity (thymus derived, or T lymphocytes) or both. Swiss-type hypogammaglobulinemia, ataxia-telangiectasia, the Wiskott-Aldrich syndrome, and severe combined immunodeficiency disorders all involve defective B-cell and T-cell function. Infantile X-linked agammaglobulinemia is caused chiefly by deficient B-cell activity, whereas thymic hypoplasia is mainly a T-cell immunodeficiency disorder.Wiskott-Aldrich syndrome, an X- linked defect, is associated with reduced IgM levels and variable cellular-mediated immunity.
Category:
Microbiology
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