Apexification Definition “Apexification is defined as chemically induced root formation by calcium hydroxide or CMCP in nonvital immature, blunderbuss canals of young permanent teeth.” APEXIFICATION  It is a method of inducing apical closure by formation of mineralized tissue in the apical region of a nonvital permanent tooth with an incompletely formed root apex.  It is defined as a method to induce development of the root apex of an immature pulpless tooth by formation of osteocementum/bone-like tissue (Cohen).  Apexification is a method of inducing apical closure through the formation of mineralized tissue in the apical pulp region of a nonvital tooth with an incompletely formed root and an open apex (Morse et al. 1990).