70 kg man was given a drug in the dose of 100 mg/kg body weight. It’s t1/2 is 10hours, initial plasma concentration is 1.9mg/ml. True statement is
Correct Answer: k is 0.0693
Description: In this patients total dose of drug administered =70 x 100 mg = 7000 mg Plasma concentration is 1.9 mg/ml Total dose administered So, volumeof distribution (Vd)= Total dose administered /Plasma concentration =7000/1.9 Again, t/2 =0.693 x(Vd/CL) Where, Vd= Volume of distribution CL = Clearance Thus, CL= 0.693x(V/t1/2) = ( 0.693/10)x(7000/1.9) = 255.3 ml/hr ~0.2 L/hr t1/2= 0.693/k k=0.693/t1/2 k=0.693/10=0.0693 Ref-KDT 7/e p30-31
Category:
Anatomy
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now