45X0 seen in
**Core Concept**
45X0 syndrome is a chromosomal disorder characterized by a deletion of part of the short arm of chromosome 1 (1p36 deletion syndrome). This condition results from a loss of genetic material, leading to various physical and developmental abnormalities.
**Why the Correct Answer is Right**
The 1p36 deletion syndrome is caused by a deletion of a specific region on the short arm of chromosome 1. This deletion disrupts the function of genes involved in growth and development, leading to a range of clinical features. Infants with 1p36 deletion syndrome often present with hypotonia, feeding difficulties, and delayed development, while older children may exhibit cognitive impairment, seizures, and characteristic facial features.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because 45X0 syndrome is not associated with a deletion of chromosome 1, but rather a sex chromosome aneuploidy.
* **Option B:** This option is incorrect because Turner syndrome (45,X) is a distinct chromosomal disorder caused by the absence of one X chromosome, rather than a deletion on chromosome 1.
* **Option C:** This option is incorrect because Cri-du-chat syndrome is caused by a deletion on the short arm of chromosome 5 (5p deletion syndrome), not chromosome 1.
* **Option D:** This option is incorrect because Prader-Willi syndrome is caused by a deletion on the long arm of chromosome 15 (15q11.2 deletion syndrome), not chromosome 1.
**Clinical Pearl / High-Yield Fact**
Delays in diagnosis of 1p36 deletion syndrome can lead to significant morbidity and mortality due to associated medical complications. A high index of suspicion and early genetic testing are essential for accurate diagnosis and management.
**Correct Answer: B. Turner syndrome**