40 yr old man presents with single erythematous plaque on the penis. Histologic examination reveals dysplastic cells throughout the epidermis . All of the following are true about the disease, patient is suffering from except?
Correct Answer: No transformation to invasive carcinoma
Description: Above history point towards diagnosis of Bowen disease Squamous cell carcinoma in situ of the penis Occurs in older uncircumcised males Grossly as a solitary plaque on the shaft of the penis Histologic examination :dysplastic cells throughout the epidermis with no invasion of the underlying stroma Intact basement membrane Factors implicated in pathogenesis of penile squamous cell carcinoma are: Poor hygiene (with resultant exposure to potential carcinogens in smegma) Smoking, HPV types 16 and 18. In 10% patients , it gives rise to invasive squamous cell carcinoma
Category:
Pathology
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