Medical MCQ - 17-year-old boy presented with complain of petechiae. O/E ,sternal tenderness is present. BM biopsy show hypercellularity and more than 20% Lymphoblast. Peripheral smear show ||| TLC and presence of lymphoblast . On X ray. retrosternal mass is seen. All are true about condition patient is suffering except?

17-year-old boy presented with complain of petechiae. O/E ,sternal tenderness is present. BM biopsy show hypercellularity and more than 20% Lymphoblast. Peripheral smear show ||| TLC and presence of lymphoblast . On X ray. retrosternal mass is seen. All are true about condition patient is suffering except?

It has good prognosis

Notch gene mutation present

An immature T-cell phenotype (Tdt/CD34/CD7 positive)

Thymic involvement is seen

Question Category:

Pathology

Correct Answer:

It has good prognosis

Description:

Above patient is most likely suffering from T-cell ALL. Points in our of above diagnosis: Peak at pubey Retrosternal mass More than 20% Lymphoblast( Tdt +, PAS +) in BM ||| TLC Lymphoblast present in blood Less common than B cell ALL Thymus ++ Notch gene mutation Gain of function Poor prognosis CD1/2/5/7 positive Immunophenotyping of immature T-cell phenotype : Tdt/CD34/CD7 positive

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