100 day Glaucoma seen in which of the following condition:
So, the core concept here is corticosteroid-induced glaucoma. This type of glaucoma is a secondary open-angle glaucoma that occurs in some patients after using corticosteroids, especially topical ones like eye drops or ointments. The mechanism involves increased intraocular pressure (IOP) due to the effects of steroids on the trabecular meshwork, which reduces the outflow of aqueous humor.
Now, the correct answer should be the condition where prolonged corticosteroid use leads to elevated IOP. The classic scenario is when patients use corticosteroid eye drops for an extended period. The "100 day" part refers to the time it takes for the IOP to rise significantly after initiating corticosteroid therapy. So, the condition would be corticosteroid-induced glaucoma.
Looking at the options, even though they're not listed here, the distractors might include other types of glaucoma like primary open-angle, angle-closure, or secondary from other causes like trauma or inflammation. The other options would be incorrect because they don't relate to the 100-day timeline or corticosteroid use. For example, primary open-angle glaucoma is chronic and doesn't have a specific time frame. Angle-closure glaucoma is acute or chronic but not related to steroids. Neovascular glaucoma is secondary to other conditions like diabetes or retinal vein occlusion, not steroids.
The clinical pearl here is to remember that corticosteroids, especially when used topically over weeks to months, can induce glaucoma. Patients with a history of corticosteroid use and elevated IOP should be evaluated for this type. Also, the term "100 day glaucoma" is a classic exam point for corticosteroid-induced glaucoma, so recognizing this term is key.
**Core Concept**
"100-day glaucoma" refers to corticosteroid-induced glaucoma, a secondary open-angle glaucoma caused by prolonged corticosteroid use. It is characterized by elevated intraocular pressure (IOP) developing 2–3 months after corticosteroid administration, due to impaired aqueous humor outflow via the trabecular meshwork.
**Why the Correct Answer is Right**
Corticosteroids (e.g., topical eye drops, oral/injected forms) reduce aqueous outflow by increasing resistance in the trabecular meshwork and altering uveoscleral pathways. The "100-day" timeline reflects the delayed onset of IOP elevation, typically observed 6–8 weeks after initiating therapy. Patients with a history of corticosteroid exposure and progressive IOP elevation without other secondary causes should prompt this diagnosis.
**Why Each Wrong Option is Incorrect**
**Option A:** Primary open-angle glaucoma (POAG) is a chronic, non-inflammatory condition without a specific time