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506 Unknown

A 50-year-old male presented to the ER with acute onset of chest pain which was retrosternal and radiated to the back along with dysphagia, regurgitation and heaburn. Patient gave history of similar episodes of chest pain in the past as well. Barium swallow and esophageal manometric studies were performed. ECG of the patient was normal. Manometry study revealed, 1. Aperistalsis in greater than 30% of the wet swallows with 20% of contractions being simultaneous 2. Amplitudes greater than 30 mm Hg in the distal three fifths of the esophagus Which of the following drugs can be used in the above condition to relieve the symptoms: –

ASildenafil
BBotulinum
COctreotide
DTerlipressin
Unknown
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513 Unknown

A 15-year-old boy presented in an unconscious state and on connecting the ECG electrodes, atrial fibrillation was diagnosed. The relatives told the doctor that the boy had similar episodes of syncope in the past as well. Lab studies revealed normal potassium and calcium levels, normal CK-MB levels. The patient died of cardiac arrest and could not be revived. When the previous records were checked some undue abnormality was noted in the ECGs. There was also a history of sudden cardiac death in the family. What is the most likely defect in the above patient: –

ASCN5A
BKCN5A
CCCN5A
DPCN5A
Unknown
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