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489 Unknown

A 55-year-old female developed ESRD due to poorly controlled diabetes. She underwent dialysis 2-3 times a week. She was advised for kidney transplant which she received from cadaveric donor. She was put on immunosuppressive therapy with azathioprine, cyclosporine, methylprednisolone and anti-thymocyte globulin. Two weeks following the surgery, the patient was discharged on medications. 2 weeks later she presented to emergency with complaints of decreased urine output. On examination, her BP was noted to be 160/95 mm hg. The region of the graft is enlarged and is tender to touch. Lab investigations revealed serum creatinine of 4 mg/dl. Her differential diagnosis includes transplant rejection and drug toxicity. Which drug could be held responsible for the above clinical scenario?

AAzathioprine
BCyclosporine
CMethylprednisolone
DATG
Unknown
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490 Unknown

A 5-day-old neonate is brought to the pediatric ER with complaints of shallow breathing The child was born at 39 weeks gestation spontaneous vaginal delivery outside the hospital. There was no antenatal care received. Parents told that the child had a normal suck and cry after bih. O/E, Generalized hypeonia Generalized rigidity Occasional spasms Foul smelling brown material around the umbilicus Microbiological examination revealed, What should be the case load of the above condition for it to be called eliminated: –

A<1 case/ 1000 live bihs
B<10 cases/ 1000 live bihs
C<100 cases/ 10000 live bihs
D<1000 cases/ 100000 live bihs
Unknown
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494 Unknown

A 30-year-old male presented to the OPD with complaints of dark-coloured urine for 1 week. The episodes usually occur in the night. No splenomegaly was observed on examination. Lab findings revealed, Increased indirect bilirubin Hemoglobinemia and hemoglobinuria Absent haptoglobin Raised LDH Hemosiderinuria Reticulocytosis Flow cytometry studies were done The drug which has been approved for the above condition works by blocking which component of the complement system: –

AC3a
BC5
CMAC complex
DC1q
Unknown
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