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2873 Unknown

A 50-year-old male patient presented to the OPD with the complaint of progressive dysphagia for 4 months both to solids and liquids but more to the solids. There was history of significant weight loss, loss of appetite, pain while swallowing, a hoarse voice and cervical lymphadenopathy. Upper GI endoscopy and barium studies were conducted. During endoscopy a sample of the lesion was also taken and sent for HPE examination: – ] All of the following are risk factors for the above disease except: –

ASmoking
BPlummer Vinson syndrome
CAchalasia cardia
DBarrett's esophagus
Unknown
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2874 Unknown

A 40-year-old non-alcoholic male patient presented to the OPD with jaundice, lethargy, ahralgia, skin pigmentation, loss of libido, polyuria, polydipsia and exeional dyspnea. O/E, Hepatosplenomegaly Increased pigmentation and spider angiomas Ahropathy Ascites Loss of body hair and testicular atrophy Iron studies were done. LFTs were deranged and insulin levels were raised. Liver biopsy was also performed. Patient had no history of intake of any long-term medication. Iron studies are: – Plasma iron – 200 microgm/dL TIBC- 300 microgm/dL Transferrin saturation -90% Serum ferritin -5000 microgm/L Liver iron -10000 microgm/ gm of dry weight Hepatic iron index – 3 Which is the most common mutation seen in the above condition: –

AC282Y
BH63D
CH62D
DC283Y
Unknown
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