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2146 Unknown

A recently diagnosed case of small cell carcinoma of lung presented with slowly progressive proximal muscle weakness along with ptosis of eyelids and diplopia. O/E: – DTRs-absent Autonomic dysfunctions like frequent dryness of mouth were present. The doctor advised repetitive nerve stimulation test. There was increase in compound muscle action potential amplitude and this increase was >100% following exercise or with high frequency repetitive nerve stimulation. On serological testing, antibodies will be found against which channels: –

AT-type of calcium channels
BP/Q type of calcium channels
CL type of calcium channels
DN- type of calcium channels
Unknown
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2149 Unknown

True about genetics of cancer –

ATopoisomerase II is useful for breaking double stranded DNA
BIncreased telomerase activity enhances anti tumour effect
CMaximum synthesis of DNA occurs during G2 phase
DTransition from G2 to M phase is important in blockage of cancer spread
Unknown
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