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148 Unknown

A 50-year-old HIV seropositive male presented to the ER with multiple episodes of generalized tonic-clonic seizures. Patient is not on HAA. CD4 count was done and it was 45/ microL. O/E, Mildly arousable Disoriented No nuchal rigidity or focal neurological deficits Gadolinium enhanced MRI and MR spectroscopy were conducted. Which is the most appropriate drug to be given in the above condition: –

ACaspofungin
BStreptokinase
CPyrimethamine + Sulphadiazine
DVoriconazole
Unknown
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153 Unknown

A 54-year-old obese man was diagnosed with NIDDM 1 year earlier. He was started on glipizide and metformin. His other medications are propranolol and nifedipine for hypertension, and naproxen, which he began 2 weeks ago for severe osteoarthritis. His BP is 154/92. His BUN is 29 mg/dL and a creatinine of 1.8 mg/dL; both had been normal 1 year earlier. Which medications is most likely responsible for the increase in BUN and creatinine?

AGlipizide
BMetformin
CNaproxen
DNifedipine
Unknown
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