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7748 Surgery

A middle-aged man presents with a markedly enlarged tonsil and recurrent infections with serum immunoglobulin deficiency. Chromosome analysis demonstrates a translocation between the immunuglobulin heavy chain locus on chromosome 14 and an unidentified gene on chromosome 8. Which of the following is the most likely cause of his phenotype?

AThe translocation has deleted constant chain exons on chromosome 14 and prevented heavy chain class switching
BThe translocation has deleted the interval containing diversity d. and joining (J) regions
CThe translocation has activated a tumor-promoting gene on chromosome 8 (Correct Answer)
DThe translocation has deleted the heavy chain constant chain Cu so that virgin B cells cannot produce IgM on their membranes