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7047 Surgery

A 46-year-old male with HIV and severe penicillin allergy receiving zidovudine, indinavir, and stavudine presents with fever, nonproductive cough, and severe hypoxia. Chest x-ray reveals diffuse increased interstitial markings and a possible lobar consolidation in the left lower lobe. After appropriate evaluation, the patient receives levofloxacin, trimethoprimsulfamethoxazole, and acyclovir. Initial serum creatinine is 1.6 mg/dL. On day 4, it has risen to 3.8 mg/dL and a normal serum potassium has risen to 7.1 mg/dL. Urinalysis reveals no casts, 10 to 20 WBC/HPF, and rare RBCs. Which drug is the most likely cause of renal failure?

ALevofloxacin
BTrimethoprim-sulfamethoxazole
CAcyclovir
DIndinavir
Surgery
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