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2919 Surgery

Which of the following is true regarding intravenous administration of chemotherapy?

ASubcutaneous extravasation of carmustine (BCNU) or 5-fluorouracil (5-FU) usually causes ulceration
BExtravasation of doxorubicin rarely causes serious ulceration because the agent binds quickly to tissue nucleic acid
CSerious and progressive ulceration can be expected following extravasation of vincristine or vinblastine
DProblems of wound healing should be anticipated if systemic 5-FU therapy is begun less than 2 week postoperatively (Correct Answer)