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13221 Surgery

A 73-year-old woman is evaluated for obstructive jaundice after an injury to the CBD, 7 months previously at laparoscopic cholecystectomy. The alkaline phosphatase is elevated. In obstructive jaundice, which of the following statements is true regarding alkaline phosphatase?

AIts level increases before that of bilirubin.
BIts level is unlikely to be increased in pancreatic malignancy.
CIts elevation indicates bone metastasis.
DIts elevation excludes hepatic metastasis.
Surgery
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