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4961 Physiology

Two normal, healthy subjects volunteer for a study on insulin secretion. In Patient 1, blood glucose is increased to 150 mg/dL by direct intravenous infusion. In Patient 2, blood glucose is increased to 150 mg/dL by ingestion of oral glucose. The peak plasma insulin concentration produced in Patient 1 is 70 uU/mL while in Patient 2, it is 95 uU/mL. Which of the following best explains the higher insulin concentration in Patient 2?

AIngested glucose activates a sympathetic reflex that increases b cell release of insulin
BIngested glucose increases duodenal secretion of gastric inhibitory peptide (GIP), increasing b cell release of insulin
CIntravenous glucose increases islet cell secretion of somatostatin, inhibiting b cell release of insulin
DIntravenous glucose increases islet cell secretion of glucagon, inhibiting b cell release of insulin
Physiology
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