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6421 Pharmacology

All of the following statements regarding bioavailability of a drug are true except –

AIt is the propoion (fraction) of unchanged drug that reaches the systemic circulation
BBioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous (iv) administration
CLow oral bioavailability always and necessarily mean poor absorption
DBioavailability can be determined from plasma concentration or urinary excretion data
Pharmacology
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6423 Pharmacology

A 56-year-old lady, who is a known case of lung cancer, presents with vomiting, headache and seizures. Investigations reveal serum osmolarity of 265 mosm/L (normal is 285-295 mosm/L) and a serum sodium level of 125 mEq/L (normal value is 136-152 mEq/L). Urine osmolarity is greater than 100 mOsm/L She has normal water intake. Which of the following drugs is useful for this patient?

AAcetazolamide
BHydrochlorothiazide
CTriamterene
DTolvaptan
Pharmacology
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6426 Pharmacology

A young female, Rama with amenorrhea, infertility, and galactorrhoea were treated with a drug that successfully restored ovulation and menstruation. Before being given the drug, the woman was carefully questioned about previous mental health problems, which she did not have. She was advised to take the drug orally. The drug used to treat this patient was probably:

ABromocriptine
BDesmopressin
CHuman gonadotropin hormone
DLeuprolide
Pharmacology
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