Mcq Subject: Pharmacology

Acetazolamide is given to a patient of angle closure glaucoma. It is a non-competitive inhibitor of carbonic anhydrase enzyme. Which of the following should be the effect of this drug?

A. Decrease in Vmax

B. A.Decrease in Km

C. Increase in both Km and Vmax

D. No change in Vmax

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Major aim of phase 1 clinical trials is:

A. Safety

B. Efficacy

C. Dose

D. Pharmacokinetics

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CYP50 inhibition is least by:

A. Pantoprazole

B. Rabeprazole

C. Lansoprazole

D. Omeprazole

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IV ultrashort acting barbiturate:

A. Meprobamate

B. Pentobarbitone

C. Thiopentone

D. Phenobarbitone

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Vitamin D toxicity is treated with

A. Chloroquine

B. Hydroxycholoquine

C. Dexamethasone

D. Ketoconazole

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Which of the following drugs can be stopped abruptly without any withdrawal symptoms?

A. Esctilaopram

B. Fluoxetine

C. Fluvoxamine

D. Seraline

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Drug adveisement letter is a necessary component of each drug formulation and contains various information about the drug like drug dosing, frequency and half-life. Which of the following information need not be given in the drug adveisement letter?

A. Research papers and other aicles proving efficacy of the drug

B. Date of expiry of the drug

C. Rare, but serious life threatening adverse-effects

D. Common, not so serious adverse-effects

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Use of lithium during pregnancy increases the risk of development of which of the following malformations in the baby?

A. Facial defects

B. Cardiac defects

C. Neural tube defects

D. Urogenital defects

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Absorption of which of the following drugs is increased after a fatty meal?

A. Amphotericin B

B. Griseofulvin

C. Ampicillin

D. Aspirin

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Which of these drugs is an antidote for fibrinolytic therapy?

A. Epsilon aminocaproic acid

B. Protamine

C. Heparin

D. Streptokinase

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