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1300 Pharmacology

Despite their sho half-lives (2 hrs), proton pump inhibitors (PPIs) cause a prolonged Suppression of acid secretion (up to 48 h) because:

AThey are prodrugs and undergo activation gradually
BThey exit from the plasma and enter acid secretory canaliculi and stay there, blocking the secretion of acid for a long time
CThey irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps
DThey irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps
Pharmacology
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