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1095 Pharmacology

The positive inotropic effect of digitalyzers is due to invitation of Na+/K+ ATPase pump in cardiac muscle cell membrane leading to

ADecrease the activity of Na+/Ca+ exchanger causing decrease the influx of sodium and decreased efflux of Ca++ in the sarcolemma
BDecreased efflux of Na+ leading to less negative resting membrane potential and opening of voltage gated Ca+ + channels on the T tubules
CIncreased intracellular Na+ causing increased efflux of any place and increase the influx of Ca + + through Na+/ Ca + + exchanges in sarcolemma
DIncreased intracellular Na+ decreasing the activity of Ca + + pump in the sarcoplasmic reticulum
Pharmacology
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