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9980 Pharmacology

An 18-year-old man who is known to have non penicillinase producing gonococcal urethritis is given an injection of penicillin and probenecid. What is the mechanism used by probenecid that makes penicillin more efficacious

APromotes entry of the penicillin into the bacteria
BProlongs the duration of action by affecting the liver metabolism of penicillin
CDecreases the bacterial resistance by inhibiting penicillinase production
DIncreases the half-life and serum level by decreasing the renal excretion of penicillin
Pharmacology
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