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9661 Pharmacology

Cardiac or central nervous system toxicity may result when standard lignocaine doses are administered to patients with circulatory failure. This may be due to the following reason :

ALignocaine concentration is initially higher in relatively well perfused tissues such as brain and heart.
BHistamine receptors in brain and heart get suddenly activated in circulatory failure
CThere is a sudden outburst of release of adrenaline, noradrenaline and dopamine in brain and heart
DLignocaine is converted to a toxic metabolite due to its longer stay in the liver.
Pharmacology
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9665 Pharmacology

The choice of antihypeensive depends upon the co-morbid illness of the patient and all of the following recommendations have been made EXCEPT

AIn hypeensive patients with hea failure, ACE inhibitors may be preferred
BIn hypeensive patients with migraines, beta blockers ,are an excellent choice
CIn hypeensive patients with gout, diuretics are paicularly useful
DIn hypeensive patients with peripheral vascular disease, calcium channel blockers are recommended
Pharmacology
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