Mcq Subject: Pharmacology

Major aim of phase 1 clinical trials is:-

A. Safety

B. Efficacy

C. Dose

D. Pharmacokinetics

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Metformin causes I severe, sometimes life-threatening side effect of lactic acidosis. All of the following factors increase the risk of lactic acidosis except:

A. Advanced age

B. Smoking

C. Liver dysfunction

D. Renal failure

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Which one of the following is penicillinase resistant penicillin:

A. Amoxycillin

B. Cloxacillin

C. Ampicillin

D. Penicillin G

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In an animal model, the phenomenon of vasomotor reversal of dale can be demonstrated by:

A. Stimulation of alpha-1 followed by stimulation of beta-2

B. Block of alpha-1 followed by stimulation of beta-2

C. Stimulation of alpha-1 followed by block of beta-2

D. Stimulation of beta-1 receptor followed by block of beta-2 receptor

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Short-acting non-depolarising muscle relaxant is:

A. Succinylcholine

B. Pancuronium

C. Mivacurum

D. Decamethonium

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Benzodiazepines are true in:

A. Produce distortion in sleep more than other sedatives

B. More safe than other sedatives when take in larger amounts

C. After metabolism of other drugs in liver

D. All have metabolically active substrates

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Which of the following drugs is not used in detoxifica-tion of chronic alcoholics?

A. Flumazenil

B. Disulfiram

C. Acamprosate

D. Naltrexone

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The drug which is used to treat laryngospasm is

A. Atropine

B. Diazepam

C. Neostigmine

D. Succinylcholine

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In iron poisoning drug Desferoxamine is given.what is its mechanism of action –

A. By binding with trivalent Fe3+

B. -by inhibiting Hepcidin

C. -by inhibiting DMT1

D. -by inhibiting ferropoin

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Which of the following drug must be sold by retail only on production of a prescription by a registered medical practitioner?

A. Schedule H

B. Schedule G

C. Schedule X

D. Schedule M

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