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2329 Pediatrics

A routine prenatal ultrasound reveals a male fetus with meningomyelocele. The 24-year-old primigravid mother is told the infant will require surgery shortly after birth. You counsel her about the etiology of this defect and the risk of further pregnancies being similarly affected, and state which of the following?

AThe hereditary pattern for this condition is autosomal recessive.
BThe prenatal diagnosis can be made by the detection of very low levels of alpha-fetoprotein in the amniotic fluid.
CSubsequent pregnancies are not at increased risk compared to the general population.
DSupplementation of maternal diet with folate leads to a decrease in incidence of this condition.
Pediatrics
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