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2281 Pediatrics

A 7-month-old child with failure to thrive is found to have a hemoglobin of 4.4 g/dL. The peripheral smear shows very small red cells with marked pallor. It is determined that the child has very low levels of hemoglobin A, with elevated fractions of hemoglobin A2 and hemoglobin F. Which of the following underlying mechanisms is most likely related to the observed findings?

AAmino acid substitution on b globin
BAntibody against fetal blood cells
CCytoskeletal protein defect
DInsufficient production of b globin
Pediatrics
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