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851 Pathology

A 52-year-old recent immigrant from Vietnam complains of abdominal swelling, weight loss, and upper abdominal pain of 3 weeks in duration. His past medical history includes malaria and infection with the liver fluke Clonorchis sinensis. The liver is hard on palpation. An abdominal CT scan shows a hypo-attenuated mass with lobulated margins in the liver. A biopsy discloses well-differentiated neoplastic glands embedded in a dense fibrous stroma. Which of the following is the most likely diagnosis?

ACarcinoma of the gallbladder
BCholangiocarcinoma
CHemangiosarcoma
DHepatocellular carcinoma
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852 Pathology

A 66-year-old woman collapses while shopping and expires suddenly of cardiac arrest. Her past medical history is significant for long-standing type 2 diabetes mellitus. Her relatives note that she had complained of chest heaviness and shoness of breath for the past 2 weeks. Sterile fibrinous pericarditis and pericardial effusion are observed at autopsy. What additional finding would be expected during autopsy of this patient?

AEndocardial fibroelastosis
BMarantic endocarditis
CMitral valve prolapse
DMyocardial infarct
Pathology
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853 Pathology

All of the following statement are true regarding silicosis, except:

ACrystalline forms are much more fibrogenic
BPhagocytosed silica crystals activate the inflammasome, leading to the release of inflammatory mediators, paicularly IL-2 and TNF
CAs the disease progresses, nodules coalesce into hard, collagenous scars
DHistologic examination reveals the hallmark lesion characterized by a central area of whorled collagen fibers with a more peripheral zone of dust-laden macrophages.
Pathology
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