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8323 Pathology

A 4 year-old boy, develops a large erythematous rash around the site of a mosquito bite. One month later, he is taken to a pediatrician because of a puffy face and swollen ankles. The scanty urine sample has a reddish-brown hue, and contains both red blood cells and protein. Which of the following distinctive features would be most likely to be seen on renal biopsy?

AFusion of podocyte foot processes
BIgA in the mesangium
CLinear IgG deposits
DSubepithelial electron dense humps
Pathology
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8325 Pathology

A 21-year-old woman presents with a 3-month history of malaise, joint pain, weight loss, and sporadic fever. The patient appears agitated. Her temperature is 38degC (101degF). Other physical findings include malar rash, erythematous pink plaques with telangiectatic vessels, oral ulcers, and non blanching purpuric papules on her legs. Laboratory studies show elevated levels of blood urea nitrogen and creatinine. Antibodies directed to which of the following antigens would be expected in the serum of this patient?

AC-ANCA (anti-proteinase-3)
BDouble-stranded DNA
CP-ANCA (anti-myeloperoxidase)
DRheumatoid factor
Pathology
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