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8239 Pathology

A 4-year-old girl has sudden onset of right hip pain. On examination, the child’s right hip is dislocated. The child can bend her thumb backward to touch the forearm. Her skin is noted to be extraordinarily stretchable. Radiographs of her spine show marked lateral and anterior curvature. She develops retinal detachments later in childhood. A sibling is similarly affected. A mutation in tenascin-X is identified. Which of the following is the most likely cause for this child’s findings?

ACongenital syphilis
BDeficient collagen synthesis
CDiet lacking in vitamin D
DMultiple congenital anomalies
Pathology
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8241 Pathology

A 15-year-old boy presented with one day history of bleeding gums, subconjunctival bleed and purpuric rash. Investigations revealed the following results: Hb-6.4 gm/dL TLC-26,500/mm3; Platelet – 35,000 mm3 Prothrombin time-20 sec with a control of 13 sec Partial thromboplastin time-50 sec and Fibrinogen 10 mg/dl Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?

AMyeloblastic leukemia without maturation
BMyeloblastic leukemia with maturation
CPromyelocytic leukemia
DMyelomonocytic leukemia
Pathology
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