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7798 Pathology

A 58-year-old man presents to the emergency depament with severe back pain. His history is negative for trauma and he has no other complaints. He denies urinary frequency, hesitancy, or dysuria. A digital rectal examination confirms the presence of a firm, hard, asymmetrical and stony prostate, suggestive of prostatic malignancy. In addition to PSA, which of the following markers can be demonstrated in the tumour cells?

AAMACR
BAFP
CPodoplanin
DOCT-3/4
Pathology
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7799 Pathology

A 54 year old white male presents with gradual onset of mild dementia, ataxic gait, and stale myoclonus. An MRI scan is normal, and an examination of his cerebrospinal fluid reveals no abnormalities, but the patient’s EEG is remarkable for recurrent bursts of high-voltage slow waves. Over the next 6 months, the patient’s dementia rapidly worsens, accompanied by general hypeonicity and profound dysahria. The patient dies sholy thereafter. Which of the following is the mostly likely neuropathological finding on autopsy?

ACerebellar hyperplasia
BDiffuse spongiform change
CMultiple lacunar infarcts
DNegri bodies
Pathology
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