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7540 Pathology

A 56-year-old man is undergoing chemotherapy for leukemia. He has developed fever, nonproductive cough, dyspnea, pleuritic chest pain, and hemoptysis over the past week. A chest CT scan shows multiple 1- to 4-cm nodular densities having surrounding areas of ground-glass infiltrate (halo sign). Bronchoalveolar lavage is performed, and microscopic examination of the fluid shows narrow branching septate hyphae. A CBC shows Hgb, 13 g/dL; Hct, 38.7%; WBC count, 2000/mL; and platelet count, 200,100/mL. He has most likely developed an infection with which of the following organisms?

AAspergillus fumigatus
BCandida albicans
CCryptococcus neoformans
DMoraxella catarrhalis
Pathology
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7542 Pathology

A one year old boy presented with hepatosplenomegaly and delayed milestones. The liver biopsy and bone marrow biopsy revealed presence of histiocytes with PAS-positive Diastase-resistant material in the cytoplasm. Electron-microscopic examination of these histiocytes is most likely to reveal the presence of:

ABirbeck's granules in the cytoplasm
BMyelin figures in the cytoplasm
CParallel rays of tubular structures in lysosomes
DElectron dense deposit in the mitochondria
Pathology
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