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7457 Pathology

A 45-year-old woman presents with a 2-month history of fatigue and recurrent fever. She also complains of tenderness below the right costal margin and dark urine. Physical examination reveals jaundice and mild hepatomegaly. The serum is positive for hepatitis B virus antigen. Which of the following best describes the mechanism of indirect virus-mediated hepatocyte cell death in this patient?

AAccumulation of abnormal cytoplasmic proteins
BImmune recognition of viral antigens on the cell surface
CGeneration of cytoplasmic free radicals
DImpaired plasma membrane Na+/K+ ATPase activity
Pathology
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