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6639 Pathology

A 72-year-old man has had increasing difficulty with urination for the past 10 years. He now has to get up several times each night because of a feeling of urgency, but each time the urine volume is not great. He has difficulty starting and stopping urination. On physical examination, the prostate is enlarged to twice its normal size but is not tender to palpation. One year ago, his serum prostate-specific antigen (PSA) level was 6 ng/mL, and it is still at that level when retested. Which of the following drugs is most likely to be effective in the treatment of this man?

AEstrogen (hormone)
BFinasteride (5a-reductase inhibitor)
CMitoxantrone (chemotherapy agent)
DNitrofurantoin (antibiotic)
Pathology
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