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6251 Pathology

In metastatic calcification:

ACalcium metabolism and serum calcium level are normal.
BCalcium metabolism is deranged and the serum calcium level is increased.
CCalcium metabolism is deranged and the serum calcium is normal.
DCalcium metabolism is normal and the serum calcium is increased.
Pathology
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6252 Pathology

A 50-year-old woman has had easy fatigability and noted a dragging sensation in her abdomen for the past 5 months. Physical examination reveals that she is afebrile. She has marked splenomegaly, but no lymphadenopathy. Laboratory studies show her total WBC count is 250,000/mm3 with WBC differential count showing 64% segmented neutrophils, 11% band neutrophils, 7% metamyelocytes, 5% myelocytes, 4% myeloblasts, 3% lymphocytes, 2% basophils, 2% eosinophils, and 2% monocytes. A bone marrow biopsy is performed, and karyotypic analysis of the cells reveals a t (9;22) translocation. Medical treatment with a drug having which of the following modes of action is most likely to produce a complete remission in this patient?

AActivating cellular caspases
BAntibody binding to EGF receptors
CDelivering normal p53 into cells with viral vectors
DInhibiting tyrosine kinase activity
Pathology
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