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6170 Pathology

A 7 year old boy presented with generalized edema.Urine examination revealed marked albuminuria.Serum biochemical examinations showedhypoalbuminaernia with hyperlipidaemia. Kidneybiopsy was undeaken. On light microscopicexamination, the kidney appeared normal. Electronmicroscopic examination is most likely to reveal:

AFusion of foot processes of the glomerular epithelial cells
BRarefaction of glomerular basement membrane
CDeposition of electron dense material in the basement membrane
DThin basement membrane
Pathology
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6172 Pathology

A 17-year-old woman is brought to the physician by her parents because “she has been acting strangely” for a couple of days. Over the past 3 months, she has experienced malaise, joint pain, weight loss, and sporadic fever. The patient appears agitated, with a temperature of 38degC (101degF). Other physical findings include malar rash, erythematous-pink plaques with telangiectatic vessels, oral ulcers, and nonblanching purpuric papules on her legs. Laboratory studies show elevated levels of BUN and creatinine. The anti-double-stranded DNA antibody test is positive. Biopsy of sun-damaged lesional skin would most likely show which of the following histopathologic findings in this patient?

AAcanthosis, parakeratosis, and neutrophils within the stratum corneum
BEarly dermal-epidermal separation mediated by eosinophils
CGranular distribution of immune complexes in the basement membrane zone
DLinear IgA deposits within dermal papillae
Pathology
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