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6112 Pathology

46-year-old woman with prominent splenomegaly presents with a 3-month history of malaise, easy fatigability, weakness, weight loss, and anorexia. A complete blood count and differential demonstrates a white blood cell count of 250,000/mm3 (normal 3,000 to 10,000/mm3 ) with a predominance of myelocytes, metamyelocytes, band cells, and segmented neutrophils. Cytogenetic analysis is most likely to reveal which of the following translocations

At(8;14)
Bt(9;22)
Ct(11;22)
Dt(14;18)
Pathology
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