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608 Pathology

During a routine checkup, a 50-year-old man is found to have blood in his urine. He is otherwise in excellent health. An abdominal CT scan reveals a 2-cm right renal mass. You inform the patient that staging of this tumor is key to selecting treatment and evaluating prognosis. Which of the following is the most important staging factor for this patient?

AHistologic grade of the tumor
BMetastases to regional lymph nodes
CProliferative capacity of the tumor cells
DSomatic mutations in the p53 tumor suppressor gene
Pathology
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