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5897 Pathology

An 80-year-old man has increasing jaundice with abdominal pain for the past 2 weeks. He has lost 4 kg over the past 5 months. On physical examination, there is the tenderness with palpable gallbladder in the right upper quadrant. An abdominal CT scan shows gallbladder and common bile duct dilation, along with a 3-cm mass in the head of the pancreas. Which of the following lesions is the most likely precursor to this mass?

AColonic neuroendocrine carcinoma
BDuodenal adenocarcinoma
CNeuroendocrine tumor
DPancreatic intraepithelial neoplasia
Pathology
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5898 Pathology

In an experiment, cell samples are collected from the bone marrow aspirates of patients who were diagnosed with lymphoproliferative disorders. Cytogenetic analyses are performed on these cells, and a subset of the cases is found to have the BCR-ABL fusion gene from the reciprocal translocation t (9;22) (q34;11). The presence of this gene results in increased tyrosine kinase activity. Patients with which of the following conditions are most likely to have this gene?

AAcute promyelocytic leukemia
BChronic myelogenous leukemia
CFollicular lymphoma
DHodgkin lymphoma, lymphocyte depletion type
Pathology
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